Assessing the reproducibility of semi-automated segmentation methods on post-operative T1 post contrast and FLAIR MRI of GBM.

Glioblastoma (GBM) account for~ 70% of adult primary brain tumours. Interrogation of post-operative disease residuum and peritumoral microenvironment is necessary for imaging biomarker development. This involves accurate delineation and segmentation of these particular regions of interest. A total of 35 post-operative T1 post contrast and T2 FLAIR MRI’s underwent segmentation by two independent readers. There was poor inter reader reproducibility in segmentations of disease residuum on post contrast T1 images, although this improved was higher for on segmentation of abnormal regions on FLAIR. Strong intra reader reproducibility suggests systematic error effects in identifying regions of interest.