Using image stimuli to drive fMRI analysis

We introduce a new unsupervised fMRI analysis method based on Kernel Canonical Correlation Analysis which differs from the class of supervised learning methods that are increasingly being employed in fMRI data analysis. Whereas SVM associates properties of the imaging data with simple specific categorical labels, KCCA replaces these simple labels with a label vector for each stimulus containing details of the features of that stimulus. We have compared KCCA and SVM analyses of an fMRI data set involving responses to emotionally salient stimuli. This involved first training the algorithm ( SVM, KCCA) on a subset of fMRI data and the corresponding labels/label vectors, then testing the algorithms on data withheld from the original training phase. The classification accuracies of SVM and KCCA proved to be very similar. However, the most important result arising from this study is that KCCA in able in …